DIAGNOSTIC SIGNIFICANCE OF CYTOKINES AND PLATELET-DERIVED FACTOR IN PERITONEAL FLUID OF WOMEN WITH EXTERNAL ENDOMETRIOSIS

DOI: https://doi.org/None

A.N. Sosnin, N.M. Kalinina, I.V. Berlev All-Russian Center of Emergency and Radiation Medicine named after A.M. Nikiforov, Optikov street, 54, Saint-Petersburg, Russian Federation, 197374

Introduction. In the structure of gynecological diseases endometriosis ranks third after inflammatory disease and uterine fibroids. Despite intensive study of the pathogenesis of endometriosis, many of the key moments remained to be unclear. In this regard, it is especially important to clarify the mechanisms of immunopathological process and to study clinical manifestations at different stages of the disease. Aim of the study. To determine the diagnostic value of determination of pro-, anti-inflammatory cytokines and platelet growth factor in peritoneal fluid of patients at various stages of endometriosis. Methods. The concentration of cytokines IL6, IL1β, TNFα, IL10, IL8, IFNγ, and platelet derived growth factor (PDGF) was determined with the use of enzyme immunoassay in the peritoneal fluid, the results were compared for the different clinical stages of endometriosis. Results. In peritoneal fluid observed increased levels of IL6, IL1β, TNFα, IL10, IL8, IFNγ, and increased concentration of PDGF in comparison with a group of normal women. There was discussed the role of cytokines and platelet-derived growth factor in the development of external genital endometriosis. Conclusion. Increased production of proinflammatory cytokines in proportion to the stage of endometriosis tells us about the necessity of the long-term monitoring for both laboratory and clinical data of patients with this disease.
Keywords: 
endometriosis, peritoneal fluid, cytokines, platelet-derived growth factor
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