RECEPTOR GENE EXPRESSION OF ESTRADIOL AND PROGESTERONE IN ENDOMETRIAL POLYP'S TISSUE OF PRE- AND POSTMENOPAUSAL PATIENTS

DOI: https://doi.org/None

E.N. Kareva, D.A. Tikhonov, L.H. Behbudova, T.N. Ivanovskaja, V.G. Breusenko Pirogov Russian National Research Medical University, Ostrovitianov str. 1, Moscow, Russian Federation, 117997

Introduction, the aim of the study. An increase of anti-relapse endometrial polyp's therapy efficiency force us to explore estradiol (mER, ERα, ERβ) and progesterone (PR-A, PR-B, PGRmC1 and mPR) gene expression level in different histological types of polyp's endometrium samples collected from pre- and postmenopausal patients. Methods: standard clinicaldiagnostic methods, the method of polymerasechain reactionin real time. Results. Patients in premenopausal period have a higher level of PR-A, PR-B, PGRmC1 and mPR receptor gene expression in glandular polyps then in glandular-fibrous polyps. Postmenopausal patients have a higher level of PR-A expression in glandular polyps and a higher ERβ-expression level in adenomatous polyps, then in a glandular-fibrous polyps. Conclusion. The level and composition of polyp's endometrium gene expression depends as on it's histological type, as on availability and duration of menopause.
Keywords: 
endometrium polyp, estradiol receptor, progesterone receptor, gene expression, postmenopause
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