SEX HORMONES AS REGULATORS OF THE LEVEL OF GROWTH FACTORS IN TUMOR TISSUES IN POLYNEOPLASIA OF FEMALE REPRODUCTIVE ORGANS

DOI: https://doi.org/None

E.M. Frantsiyants, T.I. Moiseenko, M.I. Vereskunova, M.L. Adamyan, N.V. Chernikova, V.V. Gurnak, K.P. Boiko Rostov Cancer Research Institute, 14 line 63, Rostov-on-Don, 344037, Russian Federation

Introduction. Sex hormones are known to influence on synthesis of growth factors in breast and uterus tumors, but their correlation in polyneoplasias is poorly studied. The aim of the study. The analyze local steroidogenesis, synthesis of growth factors and their correlation in tissues of neoplasms in solitary and combined growth of malignant tumor of breast and uterine myoma. Methods. The level of estrogens and their metabolites 2OHE1 and 16α-OHE1, progesterone, growth factors – vascular endothelial (VEGA), epidermal (EGF) – were studied with the use of ELISA in tissues of solitary malignant breast tumors (n=37), uterine myoma (n=27) and tumors in combined breast cancer and uterine myoma (n=36). Results. Single-type positive correlations of VEGF and EGF expression with levels of estradiol, estrone, 16α-OHE1 and negative correlation links with levels of estriol and progesterone were detected in polyneoplasias of tissues of breast cancer and uterine myoma. Conclusion. Similar in direction and strength, new correlation links between the level of growth factors and some sex hormones appear in synchronous process in tissues of malignant breast tumors and benign uterus tumors, unlike solitary processes.
Keywords: 
hormones, growth factors, breast cancer, uterine cancer
Список литературы: 
  1. Dabrosin C. Positive correlation between estradiol and vascular endothelial growth factor but not fibroblast growth factor-2 in normal human breast tissue in vivo. Clin. Cancer Res. 2005; 11: 8036–41.
  2. Garvin S., Dabrosin C. Tamoxifen inhibits secretion of vascular endothelial growth factor in breast cancer in vivo. Cancer Res. 2003; 63: 8742–8.
  3. Fujimoto J., Sakaguchi H., Hirose R. Progestins suppress estrogen-induced expression of vascular endothelial growth factor (VEGF) subtypes in uterine endometrial cancer cells. Cancer Lett. 1999; 141: 63–71.
  4. Hyder S.M., Nawaz Z., Chiappetta C. Identification of functional estrogen response elements in the gene coding for the potent angiogenic factor vascular endothelial growth factor. Cancer Res. 2000; 60: 3183–90.
  5. Greb R.R., Maier I., Wallwiener D. Vascular endothelial growth factor A (VEGF-A) mRNA expression levels decrease after menopause in normal breast tissue but not in breast cancer lesions. Br. J. Cancer. 1999; 81 (2): 225–31.
  6. Garvin S., Dabrosin C. In vivo measurement of tumor estradiol and vascular endothelial growth factor in breast cancer patients. BMC Cancer. 2008; 18 (8): 73–8.
  7. Talley L., Chhieng D.C., Bell W.C. Immunohistochemical detection of EGFR, p185(erbB-2), Bcl-2 and p53 in breast carcinomas in pre-menopausal and post-menopausal women. Biotech. Histochem. 2008; 83 (2): 5–14.
  8. de Cupis A., Favoni R.E. Oestrogen/growth factor cross-talk in breast carcinoma: a specific target for novel antioestrogens. Trends Pharmacol. Sci. 1997; 18 (7): 245–51.
  9. McBean J.H., Brumsted J.R., Stirewalt W.S. In vivo estrogen regulation of EGF-R in human endometrium. J. Clin. Endocrinol. Metab. 1997; 82: 1467–71.
  10. Ordiyanc I.M. Profilaktika i lechenie recidivov dobrokachestvennyh displaziy molochnyh zhelez. Materialy II mezhdunarodnoy ezhegodnoy konferencii «Problemy diagnostiki i lecheniya raka molochnoy zhelezy». SPb., 2005; 56–8.[Ordijanc I.M. Profilaktika i lechenie recidivov dobrokachestvennyh displazij molochnyh zhelez. Materialy II mezhdunarodnoj ezhegodnoj konferencii «Problemy diagnostiki i lechenija raka molochnoj zhelezy». SPb., 2005; 56–8 (in Russian)]
  11. Sidorova I.S., Levakov S.A., Sarancev A.N. Sostoyanie molochnyh zhelez u bol`nyh s giperplasticheskimi processami i rakom e`ndometriya v postmenopauze. Akusherstvo i ginekologiya. 2000; 1: 53–6.[Sidorova I.S., Levakov S.A., Sarancev A.N. Sostojanie molochnyh zhelez u bol’nyh s giperplasticheskimi processami i rakom jendometrija v postmenopauze. Akusherstvo i ginekologija. 2000; 1: 53–6 (in Russian)]