GENETIC POLYMORPHISM OF TOLL-RECEPTORS IN PATIENTS WITH CHRONIC VIRAL HEPATITIS C OF TRANSBAIKALIAN REGION

DOI: https://doi.org/None

D.A. Sakharova, Yu.A. Vitkovsky Chita State Medical Academy, Gorkogo str., 39A, Chita, 672090, Russian Federation

Introduction. Currently, in the pathogenesis of various diseases have been intensively studied the structure and function of innate immune receptors, a special role played by a Toll-like receptors (TLR). In the recent literature there are no comprehensive studies on the genetic polymorphism of TLR in the mechanisms of development and course of chronic hepatitis C virus (HCV). The aim of the study: comparison of frequencies of alleles and genotypes of genetic polymorphisms TLR2 (Arg753Gln), TLR3 (Phe412Leu), TLR4 (Asp299Gly), TLR4 (Thr399Ile), TLR6 (Ser249Pro), TLR9 (T-1237C) and TLR9 (A2848G) among relatively healthy people and patients with chronic viral hepatitis C (HCV) residing in the Transbaikalian region. Methods. The study involved 74 people (average age 36,9±1,1) with chronic hepatitis C and 66 healthy persons (average age 38,7±1,6). For the analysis of gene polymorphisms of Toll-like receptors used method of allele-specific polymerase chain reaction electrophoretic detection. Results. In a course of the study there were revealed all sought mutations in gomo- and a heterozygotic state except for polymorphism TLR2(Arg753Gln): we haven’t revealed any case of the carriage of the mutant genotype Gln/Gln. Established the difference in the frequency of genotype polymorphisms TLR4 (Thr399Ile) in the groups studied - in the main group notes the presence of the mutant allele of TLR4 (Thr399Ile) in the homozygous state, which is not found in healthy people (p
Keywords: 
genetic polymorphism, chronic viral hepatit C, toll-like receptors
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