EVALUATION OF OXIDATIVE STRESS AND ANTIOXIDANT CAPACITY IN PATIENTS WITH CORONARY ATHEROSCLEROSIS

DOI: https://doi.org/None

E.M. Stakhneva (1), E.V. Kashtanova (1), Ya.V. Polonskaya (1), O.V. Kamenskaya 92), E.V. Sadovsky (1), A.V. Kurguzov (2), A.M. Chernyavskiy (2), Yu.I. Ragino (1) 1 -Institution of Internal and Preventive Medicine, Bogatkova street, 175/1, Novosibirsk, 630089, Russian Federation; 2 -Meshalkin Institute of Circulatory Diseases, Rechkunovskaya street, 15, Novosibirsk, 630055, Russian Federation

Introduction. Oxidative processes in the pathogenesis of chronic cardiovascular diseases play a key role. Oxidative stress causes the damage of many cellular components, including lipids and proteins. Oxidative modification of low-density lipoprotein triggers mechanisms of formation of atherosclerotic plaques in blood vessels. The aim of study. Тo evaluate oxidative stress and the level of total antioxidant capacity of blood in patients with coronary atherosclerosis. Material and methods. The study included 60 men (46–79 years) with calcification of the coronary arteries or the aorta, who underwent to surgical treatment in the сlinic of the Meshalkin Institute of Circulatory Diseases. Oxidative biomarkers (concentration of malondialdehyde (MDA), the resistance of low-density lipoprotein (LDL) to oxidation and the overall degree of oxidative stress) as well as levels of antioxidant content in LDL α-tocopherol, retinol, β-carotene) and total antioxidant capacity in blood serum were determined. Results. In patients with coronary atherosclerosis the level of oxidative stress in the blood serum was 2,8±0,1 mmol/l, and in the control group – 1,6±0,3 mmol/l, i.e. there was recorded the activation of oxidative processes. Thus the concentration of MDA was higher by 36%, and the resistance of LDL to oxidation – by 30% if compared with control. The total antioxidant capacity of the blood was in healthy patients – 0,7±0,2 mmol/l, and in the group of patients with coronary atherosclerosis – 1,2±0,1 mmol/L. The group with coronary atherosclerosis differed from the control group in the level of oxidative damage – 75% (p
Keywords: 
oxidative stress, antioxidants, retinol, α-tocopherol, lipid peroxidation, malonic dialdehyde
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