ASSOCIATION OF TREM-1 GENE POLYMORPHISMS WITH RISK OF CORONARY ARTERY DISEASE IN RUSSIAN POPULATION

DOI: https://doi.org/None

Ponasenko A.V., Golovkin A.S., Khutornaya M.V., Kutikhin A.G., Yuzhalin A.E., Barbarash O.L., Barbarash L.S.

Introduction. Atherosclerosis, manifesting itself as acute coronary syndrome, stroke, and peripheral artery disease, is a chronic progressive inflammatory disease driven by both innate and adaptive immunity. As Triggering Receptor Expressed on Myeloid Cells-1 (TREM-1) is an important effector of the innate immune system, we hypothesized that polymorphisms within the gene encoding TREM-1 may increase risk of coronary artery disease (CAD). Aim. To investigate whether the TREM-1 gene polymorphisms are associated with risk of CAD. Methods. We performed a genetic association study on the sample of 702 consecutive Caucasian (Russian) patients with CAD and 300 age-, sex-, and ethnicity-matched healthy controls. Genotyping was carried out in 96-well format using the TaqMan SNP genotyping assay. Results. We found that the A/A genotype of the rs2234237 polymorphism, the G/G genotype of the rs6910730 polymorphism, the C/C genotype of the rs9471535 polymorphism, and the T/T genotype of the rs4711668 polymorphism were associated with higher risk of CAD according to the recessive model (OR=5,52, 95% CI=1,17–25,98, P=0,011; OR=4,28, 95% CI=1,09–16,81,P=0,021; OR=5,55, 95% CI=1,18–26,09, P=0,011, and OR=1,66, 95% CI=1,10–2,52, P=0,014, respectively, adjusted by age and gender).Conversely, the G allele of the rs1817537 polymorphism, the T allele of the rs2234246 polymorphism, and the T allele of the rs3804277 polymorphism correlated with decreased risk of CAD according to the dominant model (OR=0,57, 95% CI=0,40–0,81, P=0,0013; OR=0,59, 95% CI=0,42–0,84, P=0,003, and OR=0,58, 95% CI=0,41–0,81, P=0,0014, respectively, adjusted by age and gender). Conclusion. TREM-1 gene polymorphisms may be associated with risk of CAD in Russian population; however, their significance as predictive markers of CAD should be interpreted with caution in other populations.
Keywords: 
coronary artery disease, atherosclerosis, TREM-1, innate immunity, gene polymorphisms
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