ASSOCIATION OF INFECTIVE ENDOCARDITIS WITH GENE POLYMORPHISMS OF THE PHASE II XENOBIOTIC DETOXICATION SYSTEM ENZYMES

DOI: https://doi.org/None

Mal'tseva N.V., Laputenko T.A., Gorbatovskii Ya.A.

Introduction. Pathogenesis of infective endocarditis (IE) is not quite clear till now. In last years research of variants of the genes connected with pathogenesis of IE was performed. The aim. The investigation of IE association with gene single-nucleotide polymorphisms (SNPs) of phase II xenobiotic detoxication system (XDS) enzymes, arylamine N-acetyltransferase 2 (NAT2) and glutathione-S-transferaseP1 (GSTP1). Material and methods. 48 IE patients and 56 persons without cardiovascular pathology (control) were genotyped on polymorphic loci rs1799930, rs1208 and rs1695 by the method of allele specific polymerase chain reaction. Results. The association of rs1208 and rs1695 with IE was found, there was shown the positive correlation with the disease and the high risk of its development in carriers of Arg268Arg in NAT2 gene (OR=5,25, р=0,0049) and Ile105Val in GSTP1gene (ОR=5,4, р
Keywords: 
infective endocarditis, N-acetyltransferase, glutathione-S-transferase P1, gene, single-nucleotide polymorphism
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