MOLECULAR AND MORPHOLOGICAL EFFECTS OF PREOPERATIVE HYPOFRACTIONATION FOR RECTAL CANCER

DOI: https://doi.org/None

Kit O.I., Gevorkyan Yu.A., Soldatkina N.V., Novikova I.A., Gusareva M.A., Kozhushko M.A.

Introduction. Radiotherapy becomes a standard of combination treatment of the rectal cancer. That is why the development of its pathogenetical bases is very impotent. The aim of the study. The purpose of the study was to analyze molecular and morphological effects of preoperative hypofractionation for resectable rectal cancer. Methods. 55 patients received preoperative radiotherapy with the Teratron system and Varian Unique low-energy linear accelerator. Tumor tissues obtained during surgery were studied. DNAs in tumor cells were analyzed (CycleTEST PLUS DNA ReagentKit), as well as therapeutic pathomorphosis and the rate of postoperative complications. Results. The results showed an increase in the rate of tumors with DNA index 1,5 by 1,2 times, reduced percentage of tumor cells in S-phase of the cell cycle from 9,98±1,6 to 6,4±0,8% (p
Keywords: 
rectal cancer, radiotherapy, DNA
Список литературы: 
  1. Kit O.I. Problema kolorektal`nogo raka v nachale HHI veka: dostizheniya i perspektivy. Rossiyskiy zhurnal Gastroe`nterologii, Gepatologii, Koloproktolgii. 2013; 3 (23): 65–71. [Kit O. I. Problem of colorectal cancer at the beginning of the XXI century: achievements and prospects. Russian journal of Gastroenterology, Hepatology, Koloproctology. 2013; 3 (23): 65–71 (in Russian)]
  2. Adzhluni M. Rol` luchevoy terapii kak dopolnitel`nogo metoda lecheniya raka pryamoy kishki. Mezhdunarodnyy medicinskiy zhurnal. 2002; 5: 25–6. [Adzhluni M. The role of radiotherapy as additional method of treatment for rectal cancer. Mezhdunarodnyj medicinskij zhurnal. 2002; 5: 25–6 (in Russian)]
  3. Dvornichenko V.V., Afanas`ev S.G., Shelehov A.V., Moskvina N.A. Luchevaya terapiya v kombinirovannom lechenii raka pryamoy kishki (obzor literatury). Sibirskiy onkologicheskiy zhurnal. 2009; 1 (31): 72–7. [Dvornichenko V.V., Afanasev S.G., Shelehov A.V., Moskvina N.A. Radiotherapy in combined treatment for rectal cancer (literature review). Sibirskij onkologicheskij zhurnal. 2009; 1 (31): 72–7 (in Russian)]
  4. Agence Nationale pourle Developpement de I’Evaluation Medicale: Le choix des therapeutiques du cancer du rectum. Confrence de Cousensus. Paris. 1994; 132–4.
  5. Camma S., Giunta M., Fiorica F., et al. Preoperative radiotherapy for resectable rectal cancer: a meta-analysis. JAMA. 2000; 284: 1008–15.
  6. Gerard A., Buyse M., Nordinger B., et al. Preoperative radiotherapy as adjuvant treatment in rectal carcinoma. Ann. Surg. 1988; 208: 606–14.
  7. Stockholm Rectal Cancer Study Group: Preoperative short-term radiotherapy in operable rectal carcinoma: a prospective randomized study. Cancer. 1990; 66: 49–55.
  8. Swedish Rectal Cancer Trial: improved survival with preoperative radiotherapy in resectable rectal cancer. N. Engl. J. Med. 1997; 336: 980–7.
  9. Third report of the MRC Trial: Clinico-pathologic features of prognostic significance in operable rectal cancer in 17 centers in the U.K. Br. J. Surg. 1984; 50: 435–42.
  10. Novikova I.A., Kit O.I., Maksimov A.Yu., Snezhko A.V., Myagkov R.E., Kolesnikov E.N. Effect of preoperative chemotherapy on DNA-cytometric parameters of pancreas tumors. ASCO Annual Meeting, 2014; e15212.