ASSOTIATION OF GENES POLYMORPHISMS OF XENOBIOTICS-METABOLIZING ENZYMES WITH RECURRENT MISCARRIAGE

DOI: https://doi.org/None

Gordeeva L.A., Popova O.S., Voronina E.N., Shatalina I.V., Olennikova R.V., Nersesyan S.L., Filipenko M.L., Glushkov A.N.

Introduction. Recurrent miscarriage (RM) – a prevalent pathology in women. However, the mechanisms of its occurrence are studied insufficiently. A genetic factor may be one of the causes of RM in women. The aim of the study was to investigate the association of genes polymorphisms CYP1A1 (3801T>C, rs4646903), CYP1A2 (-163C>A, rs762551), GSTM1 (del), GSTT1 (del) and GSTP1 (c.313 A>G, rs1695; c.341 C>T, rs1138272) with RM risks in women (before 12 weeks of gestation). Methods. Null genotypes (0/0) of GSTM1 and GSTT1 were identified through multiplex real-time PCR, and CYP1 and GSTP1 genes polymorphisms was determined through TaqMan-real-time PCR. Results. The study found that CC genotype of gene CYP1A2 (-163C>A) is associated with the risk of RM in women, which is followed by ≥3 spontaneous miscarriages in early stages of gestation (OR=5,8, 95% CI: 2,17–15,27). No association of CYP1A1 (rs4646903), GSTM1 (del), GSTT1 (del) and GSTP1 (rs1695, rs1138272) genetic polymorphisms with the risk of RM in women was identified. Conclusion. Homozygous CC genotype of gene CYP1A2 (-163C>A) in women may be a risk factor for RM. The mechanisms of genetic control of RM in women require further investigation. The results may be useful to identify risk groups of developing this pathology in women.
Keywords: 
recurrent miscarriage, genetic polymorphism, genes of xenobiotics detoxication
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