INFLAMAGING: MOLECULAR-CELLULAR MECHANISMS OF FEMALE REPRODUCTIVE SYSTEM AGING

DOI: https://doi.org/10.29296/24999490-2019-03-02

1-St. Petersburg Institute of Bioregulation and Gerontology, Dynamo Ave., 3, St. Petersburg, 197110, Russian Federation; 2-D. Ott Research Institute of Obstetrics, Gynecology, and Reproductology, Mendeleevskaya Line, 3, St. Petersburg, 199034, Russian Federation; 3-St. Petersburg State University, University Embankment, 7–9, St. Petersburg, 199034, Russian Federation; 4-St. Petersburg Medical and Social Institute, Kondratyevsky pr., 72A, St. Petersburg, 195271, Russian Federation E-mail: [email protected]

Aging is a complex biological process, the main aspect of which is the accumulation of somatic changes in the body during life. Late reproductive age is associated with infertility and possible complications of pregnancy. Aging at the cellular and organ levels negatively affects reproductive function. Immune cells are proved to play a crucial role in the physiology of the reproductive system. Senescent cells are viable in vitro, in contrast to the apoptotic cells prone to programmed cell death. Senescent cells express pro-inflammatory cytokines, growth factors, and matrix metalloproteinases totally called the aging-associated secretory phenotype (SASP). Inflamaging (inflammatory aging) is an aging-associated, a chronic and systemic inflammatory condition caused by cells acquired senescence-associated secretory phenotype (SASP). In this type of cells, there is marked depression of the p16INK4a gene, which maintains the viability of the aging cells, preventing their apoptosis. This review examines the effect of cellular, «inflammatory» and immune aging on the female reproductive function.
Keywords: 
aging, ovary, corpus luteum, fallopian tubes, uterus
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