DENDRITIC CELLS IN THERAPY OF BREAST ADENOCARCINOMA

DOI: https://doi.org/10.29296/24999490-2019-04-02

A.A. Chernysheva(1), I.V. Chekhonin(2), O.I. Gurina(2), I.I. Shepeleva(2, 3), T.N. Popova(1) 1-Voronezh State University, Universitetskaya pl., 1, Voronezh, 394018, Russian Federation; 2-V.P. Serbsky National Medical Research Centre for Psychiatry and Narcology, Kropotkinskiy bystreet, 23, Moscow, 119034, Russian Federation; 3-N.I. Pirogov Russian National Research Medical University, Ostrovitianova str., 1, Moscow, 117997, Russian Federation E-mail: [email protected]

Dendritic cells (DC), as professional antigen-presenting cells with functional plasticity, are widely studied in preclinical and clinical research of vaccines against various types of malignant tumors. Some of the studies DС have proved their efficiency. However, all over the world, there is no officially approved DC vaccine for the treatment of breast cancer. Knowledge and understanding of fundamental functions of DC, as well as the development of methods enhancing the effect of such vaccines, may contribute to the progress in this direction. In this review, we consider the features of the main types of DC and their role in the pathogenesis of breast cancer. Also, we describe the mechanisms of antigen uptake, processing, and presentation. In addition, considerable attention is paid to the current research of DC-based treatment of breast adenocarcinoma as DC are studied both as monotherapy or in combination with other therapeutic strategies.
Keywords: 
breast cancer, dendritic cells, immunotherapy
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