CORRELATION BETWEEN CARDIAC TROPONIN I LEVELS AND AREA OF MYOCARDIAL VASCULAR NECROSIS IN THE PATIENTS WITH FATAL OUTCOME

DOI: https://doi.org/10.29296/24999490-2019-05-04

A.S. Pushkin(1, 4), I.A. Danilova(3), V.A. Volchkov(2, 4), A.A. Yakovlev(2, 4) 1-I.P. Pavlov First Saint Petersburg State Medical University, L’va Tolstogo str., 6–8, Saint-Petersburg, 197022, Russian Federation; 2-St. Petersburg State University, Universitetskaya Emb., 7–9, Saint-Petersburg, 199034, Russian Federation; 3-St.-Petersburg Municipal Pathoanatomical Bureau, Uchebny by-str., 5, Saint-Petersburg, 194354, Russian Federation; 4-St.-Petersburg Municipal Clinical Hospital №2, Uchebny by-str., 5, Saint-Petersburg, 194354, Russian Federation; E-mail: [email protected]

Introduction. The scale of myocardial infarction plays a key role in the prognosis of the disease. Changes in contractile activity of myocardial tissue as a result of necrosis of cardiomyocytes is the decisive factor in this issue. The aim of the study. The purpose of this study was to assess the possibility of using a high-sensitive method for cardiac troponin I test for risk stratification of the patients with myocardial infarction and for clinico-morphological prediction of the development of the disease. Materials and methods. The study was conducted on the basis of cardiac surgery center and city patho-anatomical bureau. 89 patients with a fatal outcome were admitted to the hospital with a diagnosis of acute coronary syndrome during 2016 year. The level of cardiac troponin I was tested by high-sensitive chemiluminescent method on microparticles. Histological staining was by hematoxylin and eosin, by the method of Regaud, Lie, selectively performed the PAS reaction. Results. At the analysis of the correlation between cardiac troponin I concentration and size of myocardial infarcted area, the Spearman correlation coefficient was 0,57 (p
Keywords: 
troponin, myocardial infarction, acute coronary syndrome, autopsy, cardiac markers, risk stratification
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