RELEVANT ASPECTS OF THE ACTIVATION OF MAST CELLS MECHANISMS IN ISCHEMIC AND REPERFUSION INJURY

DOI: https://doi.org/10.29296/24999490-2019-06-03

T.A. Yagudin(1, 2), V.SH. Ishmetov(1), V.V. Plechev(1), V.N. Pavlov(1), Hong-Yu Liu(2) 1-Bashkir State Medical University, Lenin street, 3, Ufa, 450000, Russian Federation; 2-Harbin Medical University, 157 Baojian Road, Nangang District, Harbin, China, 150081 E-mail: [email protected]

This article provides a modern analysis of the literature on the mechanisms of activation of mast cells (MC) because they are regulatory cells that make up an important part of the immune system and are part of the first line of defense against various pathological agents. The important role of MC in anaphylactic response and allergy was proved, but there was evidence that mast cells participate in a wider range of pathologies. Ischemic/reperfusion(I/R) injury triggers an inflammatory response and triggers a tissue damage/repair program known as immune control. The unique location of MC around the microcirculatory vessels makes them potentially the first link in response to early and specific I/R injury by releasing MC mediators. Multifunctionality and heterogeneity are the distinctive features of MC acquired as a result of different adaptations during phylogenesis. Thus, these important functions of MC, which may differ depending on the tissues in which they are located, and the various effects inherent in them during I/R are a topical issue today. This review provides a literature analysis on the role of MCs in I/R injury of myocardium, brain, kidneys, and internal organs or systems. The understanding of the mechanisms and the role of the MCs in I/R injury can help in the development of therapeutic strategies aimed at protection against specific damage
Keywords: 
ischemia/reperfusion, inflammatory response, mast cells, degranulation
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