P.K. Yablonsky(1, 2), A.O. Drobintseva(1, 3), T.S. Zubareva(1), Yu.S. Krylova(1, 4), D.O. Leonteva(1), I.M. Kvetnoy(1, 2), M.A. Paltsev(5)
1-Saint-Petersburg State Research Institute of Phthisiopulmonology of the Ministry of Healthcare
of the Russian Federation, Ligovskij avenue, 2–4, Saint-Petersburg, 191036, Russian Federation;
2-Saint-Petersburg University, Universitetskaya Embankment, 7–9, Saint-Petersburg, 199034, Russian Federation;
3-St. Petersburg State Pediatric Medical University, Litovskaya street, 2, Saint-Petersburg, 194100, Russian Federation;
4-Pavlov First Saint Petersburg State Medical University, Street L’va Tolstogo, 6–8, Saint-Petersburg, 197022, Russian Federation;
5-Lomonosov Moscow State University, Leninskie gory, 1, building 12, Moscow, 119991, Russian Federation

The review is devoted to the analysis of modern ideas about the molecular mechanisms of the pathogenesis of sarcoidosis, it describes the signaling molecules involved in the development of sarcoidosis, which can be biomarkers and targets for optimizing personalized diagnosis and targeted therapy of the disease. The aim of the study was to consider the possible mechanisms of development of granuloma and fibrosis of the lung tissue in this pathology and to characterize the molecular markers of sarcoidosis. Material and methods: the analysis and systematization of scientific literature over the past 5 years was carried out in the PubMed, Scopus and Google Scholar databases. Results. The review focuses on various subpopulations of lymphocytes, as well as angiogenic factors (VEGF and HIF-1α) and molecules associated with the development of inflammation (TNF-α, IFN type I, Janus kinase, COX-2). The possible epigenetic regulation of the processes occurring in sarcoidosis with the help of miRNAs is considered. The possibility of using the analysis of single nucleotide polymorphisms of genes to identify a risk group for the development of sarcoidosis, as well as an unfavorable prognosis for its course, is discussed.
sarcoidosis, signaling molecules, personalized diagnostics, targeted therapy

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