N.D. Potskherashvili, O. Yu. Zolnikova, V.T. Ivashkin
Sechenov First Moscow State University (Sechenov University), Russian Federation, ul. Trubetskaya 8, build. 2, Moscow, 119435

It is currently being discussed that the microbiota of the gastrointestinal tract and its metabolites affect the course of bronchial asthma (BA). The purpose to summarize the available data on the role of the intestinal microbiota in the pathogenesis of ВА. Material and methods. A analysis of the main foreign and domestic sources on PubMed / Medline, RSCI / elibrary databases over the last 25 years has been carried out. Results. In the course of the analysis of published works, the key links in the pathogenesis of ВА and changes arising from disturbance of intestinal microbiota composition (hygienic hypothesis, early prescription of antibacterial drugs) were compared. The results of studies on the role of bacterial overgrowth syndrome in the small intestine are analyzed. The results of studies where microbiota correction by prescribing probiotics and prebiotics resulted in positive effects on the course and prognosis in ВА are presented. Conclusion. A lot of data has been accumulated confirming the significant pathogenetic role of the microbiota. The positive effects of pro- and prebiotics both on the microbial composition of the intestine and on the course and prognosis in ВА allow us to consider the microbiome as a marker and a possible target in ВА therapy. All of the above dictates the need for further research in this area.
intestinal microbiota, bronchial asthma, probiotics, cytokines

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