SIGNALING MOLECULES OF TUMOR TRANSFORMATION IN TUBERCULOSIS

DOI: https://doi.org/10.29296/24999490-2022-06-02

Yu.S. Krylova(1, 2), G.G. Kudriashov(1), A.O. Nefedov(1), M.A. Dokhov(1, 3), A.O. Zakharchenko(4), P.K. Yablonskii(1, 4)
1-Saint-Petersburg State Research Institute of Phthisiopulmonology of the Ministry of Healthcare of the Russian Federation,
Ligovskij avenue, 2–4, Saint-Petersburg, 191036, Russian Federation;
2-Pavlov First Saint Petersburg State Medical University, Street L’va Tolstogo, 6–8, Saint-Petersburg, 197022, Russian Federation;
3-St. Petersburg State Pediatric Medical University, Litovskaya street, 2, Saint-Petersburg, 194100, Russian Federation;
4-Saint-Petersburg University, Universitetskaya Embankment, 7–9, Saint-Petersburg, 199034, Russian Federation

The review is devoted to the analysis of modern ideas about the molecular mechanisms of tumor transformation in tuberculosis; signal molecules are described, which may be biomarkers and targets for optimizing personalized diagnosis and targeted therapy of the disease. The aim of the study was to determine the current state of the issue and characterize the molecular markers of tumor transformation in tuberculosis. Material and methods: analysis and systematization of scientific literature over the past 10 years was performed in the PubMed, Scopus and Google Scholar databases. Results: particular attention in the review is given to the factors contributing to tumor transformation in tuberculosis. Both direct effects of Mycobacterium tuberculosis on proliferation and immune response, and indirect mechanisms of action on cells involved in inflammation processes are considered. The choice of signaling molecules to optimize the personalized diagnosis of tumor transformation in tuberculosis is substantiated.
Keywords: 
tuberculosis, tumor transformation, signaling molecules, personalized diagnostics
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