THE GENDER FACTOR EFFECT FOR THE EDOCRYNE FUNCTION OF MESENCHYMAL TISSUES IN CHILDREN AND ADOLESCENT

DOI: https://doi.org/10.29296/24999490-2023-02-08

A.V. Shestopalov(1–3), V.V. Davydov(1), G.T. Tumanyan(5), D.V. Savchuk(5), E.D. Teplyakova(5),
V.F. Shin(5), T.V. Grigorieva(4), A.V. Laikov(4), O.V. Borisenko(1), S.A. Roumiantsev(1, 2)
1-Pirogov Russian National Research Medical University, Ostrovityanova st., 1, Moscow, 117997, Russian Federation;
2-Center of Digital and Translational Biomedicine «Сenter of Molecular Health»,
Nakhimovski av., 32, 1, Moscow, 117218, Russian Federation;
3-Dmitry Rogachev National Medical Research Center of Pediatric Hematology,
Oncology and Immunology, Samory Mashela st., 1, Moscow, 117997, Russian Federation;
4-Kazan Federal University, Kremlyovskaya str., 18, Kazan, 420008, Russian Federation;
5-The Rostov State Medical University, Nakhichevansky st., 29, Rostov-na-Donu, 344022, Russian Federation

Introduction. There is take place increasing in the incidence of obesity among children and adolescents in the world. However, until now there are not exist clear views about mechanisms of that phenomenon. The aim of study. The purpose of that work is comparative analysis of metabolic status, as well as content of adipokines, myokines and some hormones in the blood of children and adolescents with obesity, dependent of gender. Methods. Quantification of the adipokines, myokines and hormones was carried out using multiplex ELISA. Results. Studies have revealed gender differences in the level of certain hormones, adipokines, and myokines, suggesting the appearance of features in the development of obesity in boys and girls. Obese girl experience compensatory changes that help limit manifestation of insulin resistance and lipotoxicity, as well as cardioprotective and neuroprotective effects. This prevents them from serious complications from the cardiovascular and central nervous system in obesity. In boy, due to the formation of gender peculiarities in the production of hormones, adipokines, and myokines, with obesity there are propose for appearance of a number of complications that worse the prognosis of disease in terms of development of its complications – type II diabetes mellitus and atherosclerosis. Conclusion. The development of obesity in children and adolescents is accompanied by the appearance of gender peculiarities on the part of the endocrine function of mesenchymal tissues.
Keywords: 
adipokines, myokines, lipid metabolism, obesity, children, аdolescents
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