THE ENDOTHELIAL NITRIC OXIDE SYNTHASE GENE POLYMORPHISMS AND THE RISK OF MISCARRIAGE

M.S. Nazarenko, O.Yu. Botkina, V.P. Puzyrev
Research Institute of Medical Genetics, Siberian Branch, Russian Academy of Medical Sciences

In the current study the association of the endothelial nitric oxide synthase (NOS3) gene G894T and VNTR polymorphisms with the risk of miscarriage in ethnically homogeneous population has been investigated. The frequency of A/B VNTR genotype was revealed to predominate among chromosomally normal dead first-trimester embryos in missed miscarriage (37%) if compared with newborns (25%; P=0,02). In dead embryos the 894TT genotype was registered less frequently (4%) than in nonagenarians (12%; P = 0,03). Thus, genotype AB VNTR is associated with increased risk (OR =1,77; 95%CI:1,11–2,83; P=0,02), and the genotype 894TT has a protective effect against of this pathology (OR = 0,29, 95%CI:0,09–0,89; P = 0,03).
Keywords: 
polymorphism, endothelial nitric oxide synthase (NOS3), missed miscarriage