COMPUTED TOMOGRAPHY AND MORPHOLOGICAL COMPARISONS THE DEGREEOF VASCULARIZATION OF FOCAL NODULAR HYPERPLASIA OF THE LIVER

U.N. Tumanova (1,2), E.A. Dubova (2), G.G. Karmazanovsky (1), A.I. Shchegolev (2)
1 -Vishnevsky Institute of Surgery, Moscow,
2 -Academician V.I. Kulakov Research Center of Obstetrics, Gynecology, and Perinatology, Moscow

Spiral computed tomography (CT) with contrast enhancement allows both to study changes of densitometric parameters in different phases of research and to get information about the features of vascularization in the focal formation of liver, which underlies the differential diagnosis of tumors. There was carried out as well comparative analysis of the characteristics of vascularization of focal nodular hyperplasia (FNH) of different size as computed tomography and morphological study of 15 patients (4 males and 11 females aged 14–68 years). All patients were undergone spiral CT with bolus contrast enhancement (on four phases of the study) preoperatively. With morphometric methods there were determined the number and total area of the lumen of branches of arteries and sinusoids on histological (stained with hematoxylin and eosin) and immunohistochemical (reaction with CD34) preparations of resected tissue from FNH With the densitometric analysis of tomograms there were established changes of the average CT density of FNH tissue depending on the phase of the research and size of FNH. For almost all the structures the increase CT density of FNH tissue was typical only in the arterial phase, most pronounced in small tumors. On histological preparations they were also determined the highest values of the number and total area of the sinusoids, and the highest values of the cross section of branches of arteries and total area of the blood vessels, which characterize the degree of vascularization of the tissue. The lowest increase of CT density, the number of sinusoids and the degree of vascularization were registered in large tumors.
Keywords: 
vascularization, computed tomography, morphometry, focal nodular hyperplasia