ФАРМАКОГЕНЕТИЧЕСКИЕ АСПЕКТЫ ПРОФИЛЯ ЭФФЕКТИВНОСТИ И БЕЗОПАСНОСТИ АНТИЛЕЙКОТРИЕНОВЫХ ПРЕПАРАТОВ В ТЕРАПИИ БРОНХИАЛЬНОЙ АСТМЫ

DOI: https://doi.org/10.29296/24999490-2018-06-04

А.К. Застрожина(1), Д.А. Сычев(2), член-корреспондент РАН, доктор медицинских наук, профессор 1-ГБУЗ «Детская государственная поликлиника №42 ДЗМ», Российская Федерация, 117463, Москва, ул. Голубинская, д. 23, корп. 2; 2-ФГБОУ ДПО «Российская медицинская академия непрерывного образования» Минздрава России, Российская Федерация, 125993, Москва, ул. Баррикадная, д. 2/1, стр. 1 E-mail: etc_@bk.ru

Эффективность терапии бронхиальной астмы (БА) остается одной из актуальнейших проблем в аллергологии и пульмонологии. Использование для лечения БА антилейкотриеновых препаратов (АЛП) в 35–78% случаев неэффективно. Кроме того, в литературе имеются данные о развитии нежелательных лекарственных реакций, связанных с приемом АЛП. Активно проводится поиск возможных генов-кандидатов, которые на том или ином этапе могут повлиять на механизм действия модификаторов лейкотриенов. Целью данного обзора было обобщить имеющуюся информацию о фармакогенетических особенностях АЛП и предположить, какие механизмы могут влиять на межиндивидуальную вариабельность эффективности и безопасности терапии БА.
Ключевые слова: 
бронхиальная астма, фармакогенетика

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