НЕЙРОПЕПТИДЫ КАК РЕГУЛЯТОРЫ ВЗАИМОДЕЙСТВИЯ КЛЕТОЧНЫХ ОСЦИЛЛЯТОРОВ РИТМОВ

DOI: https://doi.org/10.29296/24999490-2019-01-02

М.П. Чернышева, доктор биологических наук, доцент, А.Д. Ноздрачев, академик РАН Санкт-Петербургский государственный университет, Российская Федерация, 199034, Санкт-Петербург, Университетская наб., д. 7/9 E-mail: mp_chern@mail.ru

Пептидергические структуры гипоталамуса составляют основу его уникальной способности регулировать функции организма во времени, подстраивая метаболизм, энергетический обмен и двигательную активность как источники собственной энергии, к динамике поступления энергии от внешних источников, прежде всего света. Аксоны ретиногипоталамического тракта образуют синапсы на пептидергических нейронах супрахиазматических ядер (СХЯ). Для активности СХЯ как master-сlock циркадианных ритмов необходима регуляция как внутриклеточных осцилляторов, так и сетевой структуры ядра. В обзоре сделан акцент на анализе роли нейропептидов СХЯ в регуляции активности и взаимодействия клеточных осцилляторов мембраны, митохондрий, цитозоля и ядра нейронов. Обсуждается возможность участия нейропептидов в реализации иных функций – регуляции локального кровообращения и метаболизма в СХЯ.

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