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INFLAMAGING – МОЛЕКУЛЯРНО-КЛЕТОЧНЫЕ МЕХАНИЗМЫ СТАРЕНИЯ ЖЕНСКОЙ РЕПРОДУКТИВНОЙ СИСТЕМЫ
DOI: https://doi.org/10.29296/24999490-2019-03-02
Старение – сложный биологический процесс, основным аспектом которого является накопление соматических изменений в организме в течение жизни. Поздний репродуктивный возраст ассоциирован с бесплодием и возможными осложнениями наступления и течения беременности. Старение на клеточном и органном уровнях негативно влияет на репродуктивную функцию. Доказано, что иммунные клетки играют ключевую роль в функционировании репродуктивной системы, наступлении и течении беременности. Стареющие клетки экспрессируют провоспалительные цитокины, факторы роста и матриксные металлопротеиназы, которые в совокупности называются ассоциированным со старением секреторным фенотипом (SASP). Такие клетки жизнеспособны in vitro – в отличие от апоптотических клеток, которые подвергаются запрограммированной клеточной гибели. В 2014 г. C. Franceschi предложен новый термин «inflamaging» (инфламэйджинг), который характеризует хронический, слабовыраженный воспалительный процесс в разных органах при их старческой инволюции, протекающий бессимптомно и являющийся деструктивным для организма. По основным признакам инфламэйджинг значительно отличается от острого воспаления. Наиболее изученными маркерами иммунологического старения являются NF-κB, интерлейкины (ИЛ) 1, 6, 18, фактор некроза опухоли-α (TNFα). В настоящем обзоре рассматривается влияние клеточного, «воспалительного» и иммунного старения на репродуктивную функцию женщин.
Ключевые слова:
старение
Для цитирования:
Родичкина В.Р., Кветной И.М., Полякова В.О. INFLAMAGING – МОЛЕКУЛЯРНО-КЛЕТОЧНЫЕ МЕХАНИЗМЫ СТАРЕНИЯ ЖЕНСКОЙ РЕПРОДУКТИВНОЙ СИСТЕМЫ. Молекулярная медицина, 2019; (3): -https://doi.org/10.29296/24999490-2019-03-02
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