РОЛЬ КИШЕЧНОГО МИКРОБИОМА В РАЗВИТИИ ВИЧ/СПИД-ИНФЕКЦИИ

DOI: https://doi.org/10.29296/24999490-2019-05-02

Т.И. Хомякова(1), кандидат медицинских наук, Г.В. Козловская(1), А.Д. Магомедова(1), Н.Ф. Чертович(1), Ю.Е. Козловский(1), кандидат биологических наук, Ю.Г. Пархоменко(1, 2), доктор медицинских наук, профессор, Ю.Н. Хомяков(3), доктор биологических наук, кандидат медицинских наук 1-ФГБУН «НИИ морфологии человека», Российская Федерация, 117418, Москва, ул. Цюрупы, д. 3; 2-ГБУЗ «Инфекционная клиническая больница № 2» Департамента здравоохранения г. Москвы, Российская Федерация, 105275, Москва, 8-я ул. Соколиной горы, д. 15; 3-ФКУЗ «Противочумный центр» Роспотребнадзора, Российская Федерация, 127490, Москва, ул. Мусоргского, 4 E-mail: [email protected]

Синдром приобретенного иммунодефицита (СПИД) – конечная стадия развития заболевания, вызванного вирусом иммунодефицита человека (ВИЧ). В отсутствие антиретровирусной терапии между заражением и смертью больного может пройти 10 лет, при этом на продолжительность и тяжесть течения заболевания влияет ряд факторов. В последние годы доказано, что важнейшим фактором, который оказывает воздействие на иммунную активацию, процессы воспаления и развитие сопутствующих заболеваний, является микробиом толстой кишки человека. Целью данного обзора было обобщение данных, полученных при изучении роли сдвигов микробиома в развитии воспаления, иммунной активации и осложнений ВИЧ-инфекции. Приводятся также данные собственных исследований, подтверждающих эндогенный путь летального инфицирования Klebsiella pneumoniaе больных СПИД путем транслокации из толстой кишки.
Ключевые слова: 
воспаление
Для цитирования: 
Хомякова Т.И., Козловская Г.В., Магомедова А.Д., Чертович Н.Ф., Козловский Ю.Е., Пархоменко Ю.Г., Хомяков Ю.Н. РОЛЬ КИШЕЧНОГО МИКРОБИОМА В РАЗВИТИИ ВИЧ/СПИД-ИНФЕКЦИИ. Молекулярная медицина, 2019; (5): -https://doi.org/10.29296/24999490-2019-05-02
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